ea0029p510 | Diabetes | ICEECE2012
Picardi P.
, Caldeira E.
, Caricilli A.
, Saad M.
Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions. However, the potential involvement of PP2A in insulins metabolic signaling pathway is presently unknown. Brain insulin resistant state is characterized by disturbances in transducing the signal from IR/IRS/AKT, changing feeding behaviour and body weight. We showed that diet induced obese rats (DIO) have a marked increase in PP2A protein expression in the hypothalamus....